Líffræðifélag Íslands - biologia.is
Líffræðiráðstefnan 2025
Erindi/veggspjald / Talk/poster V50
Höfundar / Authors: Alda Björk Oddgeirsdóttir, Clara Valls Ferré, Vera Amanda Varis, Guðrún Valdimarsdóttir
Starfsvettvangur / Affiliations: Háskóli Íslands
Kynnir / Presenter: Alda Björk Oddgeirsdóttir
Breast cancer is the most commonly diagnosed cancer in women. Angiogenesis is crucial for tumor growth and metastasis, varying with breast cancer subtypes and angiogenic factors (Lugano et al., 2020). TGFβ family members, especially TGFβ1 and BMP9, are known to signal through endothelial receptors ALK5 and ALK1, respectively, balancing endothelial states (Goumans & ten Dijke., 2017). We have identified Thrombospondin-1 (TSP-1), an extracellular glycoprotein that inhibits angiogenesis, as a downstream target of the TGFβ–ALK5–SMAD2/3 signaling pathway, which is upregulated in quiescent endothelium. Conversely, we have suggested that Epidermal Growth Factor-Like domain 7 (EGFL7) mediates BMP9/ALK1-induced sprouting angiogenesis in endothelial cells (Richter et al., 2019). Aims: 1) Study the role of TSP-1 in the interplay between endothelial cells (ECs) and breast cancer cells (BCCs). 2) To investigate the interactions between endothelial cells and breast cancer models of luminal A and triple-negative subtypes, including both established cell lines (MCF7 and MDA-MB-231) and patient-derived tumoroids corresponding to these subtypes.