Líffræðifélag Íslands - biologia.is
Líffræðiráðstefnan 2017
Erindi/veggspjald / Talk/poster V42
Höfundar / Authors: Christian Christensen (1,2,3), Sandra Mjöll Jónsdóttir-Buch (1,2,3), Helena Montazeri (1,2), Eydís Mary Jónsdóttir (4), Steindór Runiberg Harldsson (4), Ólafur Eysteinn Sigurjónsson (1,2,3,5)
Starfsvettvangur / Affiliations: 1. Platome Líftækni, 2. Háskóli Íslands, 3. Blóðbankinn, 4. Zeto ehf., 5. Háskólinn í Reykjavík
Kynnir / Presenter: Christian Christensen
Bioactive substances derived from marine sources have various applications, including their use for skin care products. Such substances can be derived from marine organisms like algae. The ability of algae extracts to exert antioxidant effects, decrease break down of extracellular substances like collagen and reduce the aging of the skin have been reported. Laminaria digitata (kelp) is a large brown algae that grows along the coastline of Iceland, especially in Breiðafjörður. Serum from L. digitata has been used for skin care but its bioactivity is largely unknown. In this ongoing study, serum from L. digitata was derived using a novel mechanical approach without the need for additive chemicals that may reduce the bioactivity. The effects of L. digitata serum on the keratinocyte cell line, HaCaT, and bone marrow derived mesenchymal stromal cells were evaluated. HaCaT demonstrated more rapid proliferation when treated with L. digitata serum compared to the control (117.3 ± 11%) and cytotoxicity was low (2,3% ± 0,3% -5,0% ± 1.1%). The growth of mesenchymal stromal cells was reduced in the presence of L. digitata compared to the control (53,4% ± 3,9%) and their morphology changed. The cytotoxicity was though low (2,8% ± 2% - 3,0% ± 2,0%). The results indicate that serum from L. digitata does not reduce the proliferation of keratinocytes and can, in a low concentration, support active proliferation without cytotoxic effects.