Líffræðifélag Íslands - biologia.is
Líffræðiráðstefnan 2019
Erindi/veggspjald / Talk/poster E14
Höfundar / Authors: Thorunn A Olafsdottir(1,2), Fannar Theodors(1), Kristbjorg Bjarnadottir(1), Unnur Steina Bjornsdottir(3,4), Arna B Agustsdottir(1), Olafur A Stefansson(1), Erna V Ivarsdottir(1,5), Jon K Sigurdsson(1), Stefania Benonisdottir(1), Gudmundur I Eyjolfsson(6), David Gislason(4,7), Thorarinn Gislason(2,8), Steinunn Guðmundsdóttir(1,) Arnaldur Gylfason(1), Bjarni V Halldorsson(1,9), Gisli H Halldorsson(1), Thorhildur Juliusdottir(1), Anna M Kristinsdottir(1), Dora Ludviksdottir(2,7), Bjorn R Ludviksson(2,10), Gisli Masson(1), Kristjan Norland(1), Pall T Onundarson(2,11), Isleifur Olafsson(12), Olof Sigurdardottir(2,13), Lilja Stefansdottir(1), Gardar Sveinbjornsson(1), Vinicius Tragante(1,14), Daniel F Gudbjartsson(1,5), Gudmar Thorleifsson(1), Patrick Sulem(1), Unnur Thorsteinsdottir(1,2), Gudmundur L Norddahl(1), Ingileif Jonsdottir(1,2) and Kari Stefansson(1,2)
Starfsvettvangur / Affiliations: 1.deCODE genetics/Amgen, Inc., Reykjavik, Iceland. 2. Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 3. Department of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland. 4. The Medical Center Mjodd, Reykjavik, Iceland. 5. School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. 6. The Laboratory in Mjodd, RAM, Reykjavik, Iceland. 7. Department of Respiratory Medicine and Sleep, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland. 8. Department of Sleep, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland. 9.School of Science and Engineering, Reykjavik University, Reykjavík, Iceland. 10.Department of Immunology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland. 11. Department of Laboratory Hematology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland. 12. Department of Clinical Biochemistry, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland. 13. Department of Clinical Biochemistry, Akureyri Hospital, Akureyri, Iceland. 14. Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
Kynnir / Presenter: Þórunn Ásta Ólafsdóttir
Asthma is one of the most common chronic diseases affecting both children and adults. Different asthma phenotypes are defined as endotypes that differ in age of onset, environmental risk factors, clinical presentation, prognosis and response to therapies.
To search for sequence variants underlying asthma we carried out a genome-wide association meta-analysis using large sample sets from Iceland and the UK, representing the largest asthma GWAS to date. We found a total of 88 risk variants at 56 loci including 32 novel asthma loci. We tested the effect of the asthma variants on three asthma sub-phenotypes; allergic asthma, early (EOA) and late (LOA) onset asthma. Overall, the effects of the 88 asthma variants were similar on the subphenotypes although for some of the variants the effect was stronger on EOA than LOA. Further, we tested association of the 88 asthma variants with several allergic phenotypes and found stronger correlation with respiratory allergic phenotypes than with atopic dermatitis or the Th1 driven chronic-rhinosinusitis without nasal polyps. Candidate genes at the associated loci highlight the role of Th cells in asthma as well as innate immunity and airway remodeling.
In summary, our study considerably expands the number of asthma susceptibility loci and confirms many previous findings.