Líffræðifélag Íslands
Líffræðiráðstefnan 2015
Erindi/veggspjald / Talk/poster V68
Freyr Jóhannsson, Óttar Rolfsson, Ólafur Eysteinn Sigurjónsson, Steinn Guðmundsson,
1. Háskóli Íslands, 2. Kerfislíffræðisetur
Kynnir / Presenter: Freyr Jóhannsson
Tengiliður / Corresponding author: Freyr Jóhannsson (frj8@hi.is)
Platelets represent an important part of transfusion medicine on account of their hemostatic role. Modern healthcare is greatly dependent on the banking and transfusion of blood products in the form of red blood cell and platelet concentrates. Pathogen contamination is still a major threat during blood transfusion with bacterial contamination being the most frequent. To diminish the thread of pathogen transmission via blood transfusion, pathogen inactivation techniques have been developed. One such technique is the Intercept Blood System. It is already in routine use in over 20 countries, including the blood bank of Iceland . The intercept blood system consist of the photoactive compound amotostalen and UVA light treatment. Although proven to be a safe and effective method against pathogen contamination its holistic effect on platelets function has not yet been determined. Here mass spectroscopy coupled with liquid chromatography has been used to determine the effects of the intercept blood system on platelet metabolism and proteome during storage under blood bank conditions.